Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1992-10-30
1996-01-02
Fleisher, Mindy B.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
536 236, 435 693, C12P 2102, A61K 3936, C07H 2104
Patent
active
054809720
ABSTRACT:
The present invention provides a nucleic acid having a nucleotide sequence coding for Sor h I, a major allergen of Sorghum halepense, and fragments thereof. The present invention also provides purified Sor h I or at least one fragment thereof, produced in a host cell transformed with a nucleic acid sequence coding for Sor h I, or at least one fragment thereof and fragments of Sor h prepared synthetically. Sor h I and fragments thereof are useful for diagnosing, treating, and preventing allergy to Johnson grass pollen.
REFERENCES:
Ruffin et al. (1983) Environ. & Experiment. Botany vol. 23(4):311-319.
Matthiesen et al. (1991) J. Allergy Clin. Immunol. vol. 88(5):763-774.
Lowenstein et al. (1992) J. Allergy. Clin. Immunol. vol. 89 (1 part 2):151.
Watson, et al., "Etiology of Hay Fever in Arizona and the Southwest", JAMA, 1992, vol. 78, pp. 718-722.
French, S. W., "Pollens Which Cause Hay Fever in South Central Texas", 1930, J. Allergy, vol. 1, pp. 286-291.
Martin, et al., "Cross-Allergenicity Among the Grasses", Feb., 1985, vol. 54, pp. 99-104, Annals. of Aller.
Yoo, et al., "Induction of Anti-Timothy Pollen Reaginic Antibodies and their Cross-Reactivity in the Rat", Oct. 1977, Annals of Allergy, vol. 39, pp. 272-275.
Avjioglu Asil
Knox Robert B.
Singh Mohan B.
Fleisher Mindy B.
Immulogic Pharmaceutical Corporation
Schmickel David
The University of Melbourne
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