Methods for increasing uridine levels with L-nucleosides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 49, 514 68, 514218, 514533, A61K 3170, A61K 3155, C07D24104, A01N 4362

Patent

active

055676898

ABSTRACT:
A method of increasing intracellular and plasma uridine levels comprising the coadministration or sequential administration of a compound from at least two of the following groups:

REFERENCES:
patent: 4613603 (1986-09-01), Biziere et al.
patent: 4613604 (1986-09-01), Chu et al.
patent: 4874602 (1989-10-01), Calabresi et al.
patent: 4950466 (1990-08-01), Calabresi et al.
patent: 5064946 (1991-11-01), Shaver et al.
patent: 5077280 (1991-12-01), Sommadossi et al.
patent: 5141943 (1992-08-01), Naguib et al.
Jurovcik et al. Nucl. Acids. Res. 3(8):2143-2154, 1976.
The Merck Index, Eleventh Edition. Published by Merck & Co., Inc. Rahway, N.J.: 1989. pp. 504 and 743.
"Interaction Between Uridine and GABA-Mediated Inhibitory Transmission: Studies In Vivo and In Vitro," Guarneri et al., Epilepsia 26(6):666-671 (1985).
"Cytidine and Uridine Requirement of the Brain," Geiger et al., J. Neurochem. 1:93-100 (1956).
"Effects of Uridine and Inosine on Glucose Metabolism in Skeletal Muscle and Activated Lipolysis in Adipose Tissue," Kypson et al., J. Pharmacol. and Exptl. Therapeutics 199(3):565-574 (1976).
"Effect of Cytidine and Uridine on Regeneration of the Liver in Rats Poisoned with Carbon Tetra-cloride," Bushma et al., Bull. Exptl. Biol. Med. 88:1480-1483 (1980).
"Effects of Uridine on the Performance and the Metabolism on Oxygenated and Hypoxic Rabbit Hearts," Kypson et al., J. Mol. Cell. Cardiol. 10:545-565 (1978).
"Anticonvulsant Effects of Uridine: Comparative Analysis of Metrazol and Penicillin Induced Foci," C. A. Roberts, Brain Res. 55:291-308 (1973).
"Vergleichende Untersuchungen zur Hemmung des Adenosinabbaus in vitro durch Dilazep," Pohl et al., Arzheim.-Forsch. (Drug Res.) 24(11a):1901-1905 (1974).
"Zur Toxikologie von Dilazep, einer neuen koronaraktiven Substanz," Abel et al., Arzheim.-Forsch. (Drug Res.) 22(4):667-674 (1972).
"Potentiation by Dilazep of the Negative Inotropic Effect of Adenosine on Guinea-Pig Atria," Fujita et al., Br. J. Pharmac. 68:343-349 (1980).
"Metabolic Effects of Inosine and Uridine in Rabbit Hearts and Rat Skeletal Muscles," Kypson, et al., Biochem. Pharmacol. 26:1585-1591 (1977).
"Enhancement of Fluorouracil Therapy By the Manipulation of Tissue Uridine Pools," Darnowski et al., Pharmac. Ther. 41:381-392 (1989).
"Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzyllacyclouridine," Martin et al., Cancer Chemother. Pharmacol. 24:9-14 (1989).
"Effect of uridine supply on glycogen resynthesis after ischemia in the isolated perfused rat heart," J. Aussedat, Cardiovasc. Res. 17:145-151 (1983).
"Anticonvulsant Activities of .increment.-8 and .increment.-9 Tetrahydrocan-nabinol and Uridine," Dwivedi et al., Toxicol. and App. Pharmacol. 31:452-458 (1975).
"Effects of Nucleosides on Acute Left Ventricular Failure in the Isolated Dog Heart," Buckley et al., Circulation Res. VII:847-857 (Nov. 1959).
"Influence of Certain Nucleosides on Glucose Utilization in Man," Elrick et al., Metabolism X(1):46-55 (Jan. 1962).
"The Relationship Between Uracil Nucleotide Concentrations and Glycogen Synthesis in Hepatocytes From Fed And Fasted Rats," Songu et al., Metabolism 30(2):119-122 (Feb. 1981).
"Dilazep: an inhibitor of adenosine uptake with intrinsic calcium antagonistic properties," Tonini et al., J. Pharm. Pharmacol. 35:434-439 (1983).
"First Report of Management and Outcome of Pregnancies Associated with Hereditary Orotic Aciduria," Bensen et al., Am. J. Med. Gen. 41:426-431 (1991).
"Uridine Incoporation in Normal and Ischaemic Perfused Rat Heart," Aussedat et al., Mol. Phys. 6:247-256 (1984).
"Benzyllacyclouridine Reverses Azidothymidine-Induced Marrow Suppression Without Impairment of Anti-Human Immunodeficiency Virus Activity," Calabresi et al., Blood 76(11):2210-2215 (Dec. 1, 1990).
"Interaction of Uridine with Gaba Binding Sites in Cerebellar Membranes of the Rat," Guarneri et al., Neurochem. Res. 8(12):1537-1545 (1983).
"Phase I and Pharmacokinetic Studies of High-Dose Uridine Intended for Rescue form 5-Fluorouracil Toxicity," Leyva et al., Cancer Res. 44:5928-5933 (Dec. 1984).
"Enhancement of the Antitumor Activity of 5-Fluorouracil by Uridine Rescue," Klubes et al., Pharma. Ther. 41:289-302 (1989).
"Tissue-specific Enhancement of Uridine Utilization and 5-Fluorouracil Therapy in Mice by Benzylacyclouridine," Darnowski et al., Cancer Res. 45:5364-5368 (Nov. 1985).
"Clinical and Pharmacological Study of Orally Administered Uridine," van Groeningen et al., J. Natl. Cancer. Inst. 43*6):437-441 (Mar. 20, 1991).
"High-Dose 5-Fluoroucacil with Delayed Uridine Rescue in Mice," Martin et al., Cancer Res. 42:3964-3970 (Oct. 1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for increasing uridine levels with L-nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for increasing uridine levels with L-nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for increasing uridine levels with L-nucleosides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2358766

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.