Methods of indentifying solid tumors with chromosome abnormaliti

Details Methods of indentifying solid tumors with chromosome abnormaliti Methods of indentifying solid tumors with chromosome abnormaliti

1995-05-18

1996-10-22

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 231, 536 243, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

055675867

ABSTRACT:
Methods of determining whether a solid tumor has an ALL-1 gene rearrangement or an ALL-1 gene mutation are disclosed. The methods comprise the steps of obtaining a sample of a solid tumor and detecting the presence of an ALL-1 gene rearrangement or mutation in a cell in said sample. ALL-1 gene rearrangements and mutations are detected by Southern blot analysis, PCR amplification analysis, in situ hybridization analysis, Northern blot analysis or DNA sequence analysis.

REFERENCES:
Cimino et al, Cancer Research 51:6712-6714.
Solomon Science 254:1153-1160, 1991.
Kobayashi, Genes, Chromosomes and Cancer 8:246-252, 1993.
Bowden, D. et al., "Studies on Locus Expression, Library Representation, and Chromosome Walking Using an Efficient Method to Screen Cosmid Libraries", Gene 1988, 71, 391-400.
Chen, C. et al., "Breakpoint Clustering in t(4;11) (q21;23) Acute Leukemia", Blood 1991, 78, 2498-2504.
Chomczynski, P. and Sacchi, "Single-Step Method of RNA Isolation by Acid Guanidinum Thiocyanate-Phenol-Chloroform Extraction", Analytical Biochem. 1987, 162, 156-159.
Cimino, G. et al., "Cloning of ALL-1, the Locus Involved in Leukemias with the t(4;11) (q21;q23), t(9;11) (p22;q23), and t(11;19) (q23;p13) Chromosome Translocations", Cancer Res. 1991, 51, 6712-6714.
Croce, C., "Role of Chromosome Translocations in Human Neoplasia", Cell 1987, 49, 155-156.
Gu, Y. et al., "Sequence Analysis of the Breakpoint Cluster Region in the ALL-1 Gene Involved in Acute Leukemia", Cancer Research 1994, 54, 2327-2330.
Gu, Y. et al., "The t(4;11) Chromosome Translocation of Human Acute Leukemias Fuses the ALL-1 Gene, Related to Drosophia trithorax, to the AF-4 Gene", Cell 1992, 71, 701-708.
Haluska, F. et al., "Localization of the Human Jun Protooncogene to Chromosome Region 1p31-32", PNAS USA 1988, 85, 2215-2218.
Herlyn, M. et al., "Characteristics of Cultured Human Melanocytes Isolated from Different Stages of Tumor Progression", Cancer Research 1985, 45, 5670-5676.
Huebner, K. et al., "Twenty-seven Nonoverlapping Zinc Finger cDNAs from Human T Cells Map to Nine Different Chromosomes with Apparent Clustering", Am. J. Hum. Genet. 1991, 48, 726-740.
Linnenbach, A. et al., "Structural Aleration in the MYB Protooncogene and Deletion Within the Gene Encoding .alpha.-type Protein Kinase C in Human Melanoma Cell Lines", PNAS USA 1988, 85, 74-78.
Morris, S. et al., "Reassignment of the Human ARH9 RAS-Related Gene to Chromosome 1p13-p21", Genomics 1993, 15, 677-679.
Nakamura, T. et al., "Genes on Chromosomes 4, 9, and 19 Involved in 11q23 Abnormalities in Acute Leukemia Share Sequence Homology an/or Common Motifs", PNAS USA 1993, 90, 4631-4635.
Rowley, J. et al., "Mapping Chromosome Band 11q23 in Human Acute Leukemia with Biotinylated Probes: Identification of 11q23 Translocation Breakpoints with a Yeast Artificial Chromosome", PNAS USA 1990, 87, 9358-9362.
Sacchi, N. et al., "Hu-ets-1 and Hu-ets-2 Genes are Transposed in Acute Leukemias with (4;11) and (8;21) Translocations", Science 1986, 231, 379-382.
Schichman, S. et al., "ALL-1 Partial Duplication in Acute Leukemia", PNAS USA 1994, 91, 6236-6239.
Schichman, S. et al., "ALL-1 Tandem Duplication in Acute Myeloid Leukemia with a Normal Karyotype Involves Homologous Recombination Between Alu Elements", Cancer Res. 1994, 54, 4277-4280.
Shtivelman, "Fused Transcript of abl and bcr Genes in Chronic Myelogenous Leukaemia", Nature 1985, 315, 550-554.
Solomon, E. et al., "Chromosome Aberrations and Cancer", Science 1991, 254, 1153-1160.
U.S. Ser. No. 07/805,093 Dec. 11, 1991.
U.S. Ser. No. 07/888,839 May 27, 1992.
U.S. Ser. No. 07/971,094 Oct. 30, 1992.
U.S. Ser. No. 08/062,443 May 14, 1993.
U.S. Ser. No. 08/320,559 Oct. 11, 1994.
U.S. Ser. No. 08/327,392 Oct. 19, 1994.

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