Mercapto derivatives as inhibitors of nitric oxide synthase

Details Mercapto derivatives as inhibitors of nitric oxide synthase Mercapto derivatives as inhibitors of nitric oxide synthase

1995-03-24

1997-10-07

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514211, 5142242, 514368, 514665, A61K 31155, A61K 3155, A61K 3154, A61K 31425

Patent

active

056749074

ABSTRACT:
This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto derivative and a pharmaceutically acceptable carrier. The invention also concerns a method of inhibiting nitric oxide synthase, selectively inhibiting the inducible isoform of nitric oxide synthase, and treating various conditions where there is an advantage in inhibiting nitric oxide biosynthesis. The method includes the step of administering to a mammal a mercapto derivative in pure form or in a pharmaceutically acceptable carrier.

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