2-Decarboxy-2-hydroxymethyl-11-deoxy-PGE.sub.2 analogs

Details 2-Decarboxy-2-hydroxymethyl-11-deoxy-PGE.sub.2 analogs 2-Decarboxy-2-hydroxymethyl-11-deoxy-PGE.sub.2 analogs

1977-04-06

1978-05-09

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 4946, C07C 4980, C07C 4982

Patent

active

040886948

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
derwent Farmdoc CPI 76109U-B (German Offenlegungsschrift, No. 2,323,127, 09-05-72).

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