Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-06-06
1996-10-22
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
128898, 424489, 424490, 525 541, 525 542, 525408, 525413, 525415, 5147721, 5147723, 514773, 514777, 528354, 528361, A61K 958, C08G 6308, C08G 6700
Patent
active
055674356
ABSTRACT:
Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.
REFERENCES:
patent: 4298002 (1981-11-01), Ronel et al.
patent: 4352883 (1982-10-01), Lim
patent: 4376839 (1983-03-01), Malin
patent: 4391909 (1983-07-01), Lim
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4716203 (1987-12-01), Casey et al.
patent: 4741337 (1988-05-01), Smith et al.
patent: 4741872 (1988-05-01), De Luca et al.
patent: 4889722 (1989-12-01), Sheffield et al.
patent: 4913903 (1990-04-01), Sudmann et al.
patent: 4925677 (1990-05-01), Feijen
patent: 4942035 (1990-07-01), Churchill et al.
patent: 4950596 (1990-08-01), Cheng et al.
patent: 4957744 (1990-09-01), della Valle et al.
patent: 5206303 (1993-04-01), Tse et al.
patent: 5410016 (1995-04-01), Hubbell et al.
Pagidas & Tulandi, "Effects of Ringer's lactate, Interceed (TC7) and Gore-Tex Surgical Membrane on postsurgical adhesion formation," Fertility and Sterility, 57(1):199-201, 1992, published in Birmingham, AL.
Menzies & Ellis, "The Role of Plasminogen Activator in Adhesion Prevention," Surgery, Gynecology & Obstetrics, 172:362-366, 1991, published in Chicago, IL.
Diamond et al., "Synergistic effects of Interceed (TC7) and heparin in reducing adhesion formation in the rabbit uterine horn model," Fertility and Sterility, 55(2):389-394, 1991, published in Birmingham, AL.
Steinleitner et al., "Poloxamer 407 as an Intraperitoneal Barrier Material for the Prevention of Postsurgical Adhesion Formation and Reformation in Rodent Models for Reproductive Surgery," Obstetrics & Gynecology, 77(1):48-52, 1991, published in New York.
Dupuy et al., "Microencapsulation of isolated pituitary cells by polyacrylamide microlatex coagulation on agarose beads," Biomaterials, 12:493-496, 1991, published in England.
Dunn et al., "Synergistic effect of intraperitoneally administered calcium chanel blockade and recombinant tissue plasminogen activator to prevent adhesion formation in an animal model," Am. J. Obstet. Gynecol., 164(5):1327-1330, 1991, published in St. Louis, MO.
Wujek et al., "A Carbohydrate Polymer that Effectively Prevents Epidural Fibrosis at Laminectomy Sites in the Rat," Exp. Neurology, 114:237-245, 1991, publighed in San Diego, CA.
Urman et al., "Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model," Fertility and Sterility, 56(3):563-567, 1991, published Alabama.
Gibble & Ness, "Fibrin glue: The perfect operative sealant?," Transfusion, 30(8):741-747, 1990, published in Arlington, VA.
Leach & Henry, "Reduction of postoperative adhesions in the rat uterine horn model with poloxamer 407," Am. J. Obstet. Gynecol., 162(5):1317-1319, 1990, published in St. Louis, MO.
Fuertges & Abuchowski, "The Clinical Efficacy of Poly(Ethylene Glycol)-Modified Proteins," J. of Controlled Release, 11:139-148, 1990, published in the Netherlands.
Tulandi et al., "Treatment-dependent and treatment-independent pregnancy among women with periadnexal adesions," Am. J. Obstet. Gynecol., 162(2):354-357, 1990, published in St. Louis, MO.
Urman & Gomel, "Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation and reformation in the rat model," Fertility and Sterility, 56(3):568-570, 1990, published in Alabama.
Doody et al., "Recombinant tissue plasminogen activator reduces adhesion formation in a rabbit uterine horn model," Fertility and Sterility, 51(3):509-512, 1989, published in Alabama.
Gabbay et al., "New Outlook on Pericardial Substitution After Open Heart Operations," Ann. Thorac. Surg., 48:803-812, 1989, published in New York.
Interceed (TC7) Adhesion Barrier Study Group, "Prevention of postsurgical adhesions by Interceed (TC7), an absorbable adhesion barrier: a prospective, randomized multicenter clinical study," Fertility and Sterility, 51(6):933-938, 1989, published in Alabama.
Cohn & Younes, "Biodegradable PEO/PLA block copolymers," J. Biomed. Materials Research, 22:933-1009, 1988, published in New York.
Thompson et al., "Fibrin Glue: A Review of its Preparation, Efficacy, and Adverse Effects as a Topical Hemostat," Drug Intelligence and Clinical Pharmacy, 22:946-952, 1988 published in U.S.A.
Stevenson & Sefton, "Graft copolymer emulsions of sodium alginate with hydroxyalkyl methacrylates for microencapsulation," Biomaterials, 8:449-457, 1987, published in England.
Punnonen & Viinamaki, "Polyethylene glycol 4000 in the prevention of peritoneal adhesions," Fertility and Sterility, 38(4):491-492, 1982, published in Alabama.
Omata et al., "Stereoselective Hydrolysis of dl-Menthyl Succinate by Gel-Entrapped Rhodotorula minuta var. texensis Cells in Organic Solvent," European J. Appl. Microbiol. Biotechnol., 11:199-204, 1981, published in Germany.
Goosen et al., "Optimization of Microencapsulation Parameters: Semipermeable Microcapsules as a Bioartificial Pancreas," Biotech. and Bioengin., 27:146-150, 1985, published in New York.
Sefton et al., "Hydrophilic Polyacrylates for the Microencapsulation of Fibroblasts of Pancreatic Islets," J. of Controlled Release, 6:177-187, 1987, published in the Netherlands.
Park & Hoffman, "Immobilization of Arthrobacter Simplex Cells in Thermally Reversible Hydrogels: Comparative Effects of Organic Solvent and Polymeric Surfactant on Steroid Conversion," Biotechnology Letters, 11(1):17-22, 1989, published in England.
Wong et al., "The Viability and Regeneration of Artificial Cell Microencapsulated Rat Hepatocyte Xenograft Transplants in Mice," Biomat., Art Cells, Art Org., 16(4):731-739, 1988, published in New York.
Lamberti et al., "Microencapsulation of Mammalian Cells in Polyacrylates," Applied Biochem. and Biotech., 10:101-104, 1984, published in New Jersey.
Dupuy et al., "In situ polymerization of a microencapsulating medium round living cells," J. of Biomedical Materials Research, 22:1061-1070, 1988, published in New York.
McMahon et al., "Feasibility of Cellular Microencapsulation Technology for Evaluation of Anti-Human Immunodeficiency Virus Drugs In Vivo," J. of the Natl. Cancer Institute, 82(22):1761-1765, 1990 published in U.S.A.
Gin et al., "Agarose encapsulation of islets of Langerhans: reduced toxicity in vitro," J. Microencapsulation, 4(3):239-242, 1987, published in England.
Iwata et al., "Evaluation of Microencapsulated Islets in Agarose Gel as Bioartificial Pancreas by Studies of Hormone Secretion in Cultre and by Xenotransplanatation," Diabetes, 38(1):224-225, 1989, published in U.S.A.
Darquy & Reach, "Immunoisolation of pancreatic B cells by microencapsulation--an in vitro study," Diabetologia, 28:776-780, 1985, published in Germany.
Oshea & Sun, "Encapsulation of Rat Islets of Langerhans Prolongs Xenograft Survival in Diabetic Mice", Diabetes, 35:943-946, 1986, published in U.S.A.
Desai et al., "The short-term blood biocapatibility of poly(hydroxyethyl methacrylate-co-methyl methacrylate) in an in vitro flow system measured by digital videomicroscopy," J. Biomater. Sci. Polymer Edn., 1(2):123-146, 1989, published in the Netherlands.
Fouassier & Chesneau, "Polymerisation Induite sous Irradiation Laser Visible, 4--Le Systeme Rosine/Photoamorceur Ultra-Violet/Amine," Makromo1. Chem., 192:245-260, 1991, published in Switz
Desai Neil P.
Hill-West Jennifer L.
Hubbell Jeffrey A.
Pathak Chandrashekhar P.
Sawhney Amarpreet S.
Board of Regents , The University of Texas System
Dodson Shelley A.
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