Episomal vector systems and related methods

Details Episomal vector systems and related methods Episomal vector systems and related methods

1993-12-02

1997-10-07

Chouch, Deborah

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435 694, 435 695, 435 696, 435 701, 4352401, 4353201, 935 60, C12P 2106, C12P 2102, C12P 2104, C12N 1500

Patent

active

056747039

ABSTRACT:
An episomal vector sytem and methods for use in gene therapy in humans and animals. The vector contains a papilloma virus origin of replication, a vector maintenance sequence, a first promoter transcriptionally linked to a therapeutic nucleic acid sequence, a second promoter transcriptionally linked to a papilloma virus E1 gene sequence, and a third promoter transcriptionally linked to a papilloma virus E2 gene sequence or an E1/E2 fusion gene. The vector is capable of episomal replication in human or animal cells.

REFERENCES:
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Chen et al., "The Primary Structure and Genetic Organization of the bovine Papillomavirus Type 1 Genome", 299 Nature 529, 1987.
Ledley, "Somatic Gene Therapy for Human Disease: Background and Prospects. Part 1", 110(1) J. Pediatrics 1, 1987.
Lusky et al., "A Bovine Papilloma Virus Type 1--Encoded Modulator Function is Dispensable for Transient Viral Replication But is Required for Establishment of the Stable Plasmid Site", 60(2) J. Virology 729, 1986.
Sarver et al., "Bovine Papilloma Virus Deoxyribonucleic Acid: A Novel Eucaryotic Cloning Vectro", 1(6) Molec. Cell Biol. 486, 1981.
Spalholz et al., "Transactivation of a Bovine Papilloma Virus Transcriptional Regulatory Element by the E2 Gene Product", 42 Cell 183, 1985.
Ustav et al., "Identification of the Origin of Replication of Bovine Papillomavirus and characterization of the Viral Orgin Recognition Factor E1", 10 (13) EMBO J. 4321, 1991.
Ustav and Stenlund, "Transient Replication of BPV-1 Requires Two viral Polypeptides Encoded by the E1 and E2 Open Reading Frames", 10(2) EMBO J. 449, 1991.
Culver et al., "In vivo Gene Transfer with Retroviral Vectro-Producer Cells for Treatment of Experimental Brain Tumors", 256 Science 1550, 1992.
Lusky et al., "Characterization of the Bovine Papilloma Virus Plasmid Maintenance Sequences", 36(2) Cell 391, 1984.

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