Aerosol formulations containing P134a and salbutamol

Details Aerosol formulations containing P134a and salbutamol Aerosol formulations containing P134a and salbutamol

1995-05-19

1997-10-07

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, 514826, A61K 912

Patent

active

056744714

ABSTRACT:
The invention relates to a pharmaceutical aerosol formulation consisting essentially of particulate medicament which is salbutamol or a physiologically acceptable salt or solvate thereof and 1,1,1,2-tetrafluoroethane as propellant, which formulation contains less than 0.0001% surfactant based upon the weight of medicament, particulate medicament being present in an amount of 0.005% to 5% w/w relative to the total weight of the formulation and having a particle size of less than 100 microns, with the provisos that when said formulation consists of salbutamol and 1,1,1,2-tetrafluoroethane in a weight ratio of 0.05:18, said salbutamol is present in the form of a physiologically acceptable salt and when said formulation consists of salbutamol or salbutamol sulphate and 1,1,1,2-tetrafluoroethane the weight to weight ratio of medicament to propellant is other than 69:7900 or 0.866%.

REFERENCES:
patent: 2868691 (1959-01-01), Porush et al.
patent: 2885427 (1959-05-01), Rob et al.
patent: 3014844 (1961-12-01), Thiel et al.
patent: 3219533 (1965-11-01), Mullins
patent: 3320125 (1967-05-01), Grim
patent: 3809294 (1974-05-01), Torgeson
patent: 3897779 (1975-08-01), Hansen
patent: 4044126 (1977-08-01), Cook et al.
patent: 4174295 (1979-11-01), Bargigia et al.
patent: 4347236 (1982-08-01), Tanskanen
patent: 4405598 (1983-09-01), Brown
patent: 4814161 (1989-03-01), Jinks et al.
patent: 5118494 (1992-06-01), Schultz et al.
patent: 5126123 (1992-06-01), Johnson
patent: 5182097 (1993-01-01), Byron et al.
patent: 5190029 (1993-03-01), Byron et al.
patent: 5202110 (1993-04-01), Dalby et al.
patent: 5225183 (1993-07-01), Purewal et al.
patent: 5230884 (1993-07-01), Evans
Oberholz, Frankfurter Allgemeine Zeitung, Oct. 1989, vol. 25, No. 207, p. 7.
Dalby et al., Pharmaceutical Technology, Mar. 1990, vol. 14, No. 3, pp. 26-33.
Amzacort.TM. carton, William H. Rorer, Inc., Fort Washington, Pennsylvania, USA 19034, 1986.
Pharmaceutical Journal, Sep. 29, 1990, vol. 245, pp. 428-429.
The Theory and Practice of Industrial Pharmacy, 2nd Ed., 1976 (Philadelphia, PA: Lea and Febiger), pp. 270 and 276-278.
Handbook of Aerosol Technology, 2nd Edition, 1979 (New York, New York: Van Nostrand Reinhold Company), pp. 30, 32, 33, 166, 167, 232, 233.
U.S. Senate Hearings, 12-14 May 1987, 343-347, 437 (U.S. Government Printing Office, Washington, D.C., 1987), CIS: 1987-S321-26.
Hagers Handbook of Pharmaceutical Practice, 1971, pp. 342-354 (Berlin: Springer-Verlag).

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