Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1990-08-17
1992-04-14
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, A01N 4500, C07J17200
Patent
active
051048647
ABSTRACT:
A method for reversing loss of bone mass or bone mineral content in a human being suffering from osteoporosis disclosed which comprises administering to the human being a daily dosage of at least 2.0 micrograms/day of 1-alpha-hydroxy-Vitamin D.sub.2.
REFERENCES:
patent: 4225596 (1980-09-01), DeLuca
patent: 4588716 (1986-05-01), DeLuca
Sjoden et al: "Effects of OHD.sub.2 Bone Tissue"; Acta. Endocrinol. (Copenh.) vol. 16, Nr. 4, Aug. 1984, pp. 564-568.
Sjoden et al: Proc. Soc. Exp. Biol Med. 178:432-436 (1985).
Foles, et al., "Long Term Treatment with 1.alpha.(OH)D.sub.3 for Postmenopausal Osteoporosis: Efficacy and Safety", Osteoporosis 1987-2, C. Christianson, J. S. Johansen, R. J. Rus (eds.), Osteopress ApS, Copenhagen (1987), pp. 971-973.
Lam et al., "1.alpha.-hydroxy Vitamin D.sub.2 : A Potent Synthetic Analog of Vitamin D.sub.2," Science, vol. 186, Nr. 4168, 1974, pp. 1038-1040.
Reeve, L. E., et al., "Biological Activity of .alpha.-hydroxy Vitamin D.sub.2 in the Rat," Arch. Biochem. Biophys. vol. 186, Nr. 1, Feb. 1978, pp. 164-167.
Sjoden, et al., J. Nutr. 114:2043-2046 (1984).
Physician's Desk Reference, Edition 43, pp. 1746-1748 (1988).
Tanaka, Y., et al., Endocrinology. 1973; 92:417-422.
Sorensen, O. H., et al., Clin. Endocrinol. 1977; 7:169s-175 s.
Hoikka V., et al., Acta. Med. Scand. 1980; 207:221-224.
Shiraki, M., Endocrinol. Japon. 1985; 32:305-315.
Aloia, J. et al., Amer. J. Med. 1988; 84:401-408.
Brown, et al., Lancet 1984; 1:1091-1093.
Podenphant, J., et al., Acta. Med. Scand. 1985; 218:329-333.
Caniggia, et al., Calcif. Tissue Int. 1986; 38:328-332.
Duda, et al., J. Clin. Invest. 1987; 79:1249-1253.
Zerwekh, et al., J. Clin. Endocrinol. Metabol. 1985; 60:615-617.
Horst, et al., Anal. Biochem. 1981; 116:189-203.
Horst, et al., Biochem. J. 1982; 204:185-189.
Sommerfeldt, et al., J. Nutr. 1983; 113:2595-2600.
Brautbar, N., Nephron. 1986; 44:161-166.
Biship Charles W.
DeLuca Hector F.
Gallagher John C.
Mazess Richard B.
Bone Care International, Inc.
Criares T. J.
Gulbrandsen Carl E.
Waddell Frederick E.
LandOfFree
Method for treating and preventing loss of bone mass does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treating and preventing loss of bone mass, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating and preventing loss of bone mass will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2349417