Analogues of pyrrolo[3,2d]pyrimidin-4-ones

Details Analogues of pyrrolo[3,2d]pyrimidin-4-ones Analogues of pyrrolo[3,2d]pyrimidin-4-ones

1989-04-10

1990-05-08

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544280, 544321, A61K 31505, C07D48704

Patent

active

049238728

ABSTRACT:
The present invention is novel derivatives of pyrrolo[3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.

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