Heparan sulfate biosynthesis primers

Details Heparan sulfate biosynthesis primers Heparan sulfate biosynthesis primers

1990-11-09

1992-04-14

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514172, A61K 3158, A61K 4500

Patent

active

051048566

ABSTRACT:
Conjugates of .beta.-D-xylose with estrogens or modified forms of estrogens are effective in stimulating the synthesis of heparan sulfate, and inhibiting the production of proteoglycan in animal subjects. Accordingly, these conjugates are useful in treating conditions where antithrombotic or antiproliferative activity is desirable.

REFERENCES:
patent: 4882315 (1987-01-01), Chiodini et al.
Esko et al., J. Biol. Chem. (1988) 262:12189-12195.
Lugemwa et al., Glyconjugate J. (1989) 6:457 (Abstract No. 248).
Robinson et al., Biochem. J. (1981) 194:575-586.
Robinson et al., Biochem. J. (1981) 194:839-846.

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