Solubilization of hydrophobic materials using lysophospholipid

Details Solubilization of hydrophobic materials using lysophospholipid Solubilization of hydrophobic materials using lysophospholipid

1986-01-22

1990-05-08

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

424450, A61K 31685, A01N 5726, A01N 4316

Patent

active

049238540

ABSTRACT:
A method and composition are described for the solubilization of hydrophobic materials using a lysophospholipid. The method includes drying a composition comprising a hydrophobic material-solubilizing effective amount of phospholipid from organic solvent and hydrating the resulting film with an aqueous medium at either a pH of between about 8.5 and about 14.0, or at pH 7.0 followed by reduction of the temperature to less then 0.degree. C.

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The Merck Index, 10th Ed., (1983), #1937 Cephalins; #7395, Plasmalogens.
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Cullis et al., Polymorphic Phase Behavior of Lipid Mixtures as Detected by .sup.31 P-NMR. 1978, BBA 507, pp. 207-218.
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Peterson et al., Characterization of the Interactions Between Lysophosphatides, Triton X-100, and Sarcoplasmic Retriculum, 1977, Arch. Biochem. Biophys. 179, pp. 218-228.

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