High speed, high power apparatus for vesicle prealignment, porat

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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4351722, 4351721, 435289, 935 52, 935 85, 935 93, 204299R, 2041831, C12N 1300, C12N 1500

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active

049238140

ABSTRACT:
A high speed, high voltage apparatus using homogeneous, uniform electric fields to treat vesicles carried in a suspension. In one embodiment, parallel electrodes are used to perform dielectrophoretic bunching, rotational prealignment, electro-fusion, and poration of vesicles. In another embodiment, a magnetic electrodeless apparatus is used to perform the treatment. Both embodiments are driven by a high speed, high voltage electronic supply system that utilizes a triggered ionization breakdown delivery system.

REFERENCES:
patent: 4081340 (1978-03-01), Zimmerman et al.
patent: 4289756 (1981-09-01), Zimmerman
patent: 4441972 (1984-04-01), Pohl
patent: 4476004 (1984-10-01), Pohl
patent: 4578168 (1986-03-01), Hofmann
patent: 4622302 (1986-11-01), Sowers
patent: 4663292 (1987-05-01), Wong et al.
patent: 4695547 (1987-09-01), Hilliard et al.
patent: 4784737 (1988-11-01), Ray et al.
patent: 4800163 (1989-01-01), Hibi et al.
patent: 4804450 (1989-02-01), Mochizuki et al.
patent: 4832814 (1989-05-01), Root
"Effects of High Electric Fields on Micro-Organisms" by J. H. Sale, W. A. Hamilton, Biochimica et Biophysica Act A 163 (1968), 37-43.
"Formation and Resealing of Pores of Controlled Sizes in Human Erythrocyte Membranes" by Kinosita and Tsong, Nature, vol. 268, Aug. 4, 1977.
"Hemolysis of Human Erythrocytes by a Transient Electric Field" by Kinosita & Tsong, Proc. Natl. Acad. Sci. USA, vol. 74, No. 5, pp. 1923-27, May 1977.
"Use of Voltage Pulses for the Pore Opening and Drug Loading, and the Subsequent Resealing of Red Blood Cells": by Tsong & Kinosita, Biblthca Haemat, No. 51, pp. 108-114, (Karger, Basel 1985).
"The Effect of Encapsulation in Red Blood Cells on the Distribution of Methotrexate in Mice" by U. Zimmerman and G. Pilwat, J. Clin. Chem. Clin. Biochem, vol. 16, 1978, pp. 135-144.
Dielectrophoresis by F. Pohl, Cambridge Press 1978, Chap. 4.
"Cell Fusion Induced by High Electric Impulses Applied to Dictyostelium" by E. Neumann et al., Naturw issenchaften 67, S. 414, (1980).
"Fusion of Avena Sativa Mesophyll Protoplasts by Electric Breakdown", Biochimica et Biophysica Acta, 641 (1981, p. 160-165) by U. Zimmerman et al.
Electric-Field Induced Cell-to-Cell Fusion, U. Zimmermann and J. Vienken, J. Membrane Biol. 67, 165-182, (1982).
"The Behavior of Unicellular Organisms in an Electromagnetic Field" by Teixeirn-Pinto, Experimental Cell Research 20, 548-564, (1960).
"Biochimica et Biophysica Acta", 694 (1982), 238-239, Electric Field-Mediated Fusion and Related Electrical Phenomena, U. Zimmerman.

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