Process for preparing a dihydropyridine derivative

Details Process for preparing a dihydropyridine derivative Process for preparing a dihydropyridine derivative

1981-08-20

1983-06-07

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546296, C07D21102, C07D21186

Patent

active

043872301

ABSTRACT:
Dihydropyridines of formula ##STR1## where R.sup.6 is lower alkyl and R.sup.5 is lower alkyl or aryl (lower)alkyl are prepared by a novel process from sodium or potassium salts of 1-substituted-1,6-dihydro-5-hydroxy-3[2H]-pyridones. The dihydropyridines are useful as intermediates for pharmacologically active 1-optionally substituted-3-phenyl or substituted phenylpiperidin-5-ols and esters. Some of the piperidinols and esters are novel; those where the 1-substituent is aryl(lower)alkyl are intermediates, those where the 1-substituent is cycloalkyl(lower)alkyl are analgesics or antidepressants and those in which the 1-position is unsubstituted are anti-secretory agents.

REFERENCES:
patent: 4083850 (1978-04-01), Koeda et al.
patent: 4216218 (1980-08-01), Klioze et al.
patent: 4248876 (1981-02-01), White

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