Process for producing coumarin derivatives

Details Process for producing coumarin derivatives Process for producing coumarin derivatives

1990-12-21

1993-07-27

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31120

Patent

active

052311945

ABSTRACT:
A process for producing a coumarin derivative represented by formula (II): ##STR1## wherein R.sub.1 to R.sub.4 are as defined in the specification, comprising the step of: subjecting to a ring formation and dehydrogenation reaction a 3-(2-cyclohexanoyl)-propionic acid ester derivative represented by formula (I): ##STR2## wherein R.sub.1 to R.sub.4 are as defined in the specification, the ring formation and dehydrogenation reaction being (1) conducted by use of a catalyst comprising a carrier having supported thereon palladium and either of chromium oxide and chromium hydroxide, or (2) conducted by use of a catalyst comprising a carrier having supported thereon palladium or a catalyst comprising a carrier having supported thereon palladium and either of chromium oxide and chromium hydroxide, in the presence of a promoter which is at least one member selected from the group consisting of magnesium trisilicate, zirconia, metallic chromium, and metallic tungsten.

REFERENCES:
patent: 2542965 (1951-02-01), Levesque
patent: 3442910 (1969-05-01), Thweatt
patent: 3925422 (1975-12-01), Schaafsma et al.
patent: 3936473 (1976-02-01), Symon et al.
patent: 4772728 (1988-09-01), Korte et al.
"Preparation and catalytic hydrogenation of 4,6-dimethyl-and 4,7-dimethyl-8-methoxycoumarins. A 4-methyldihydrocoumarin synthesis", Chemical Abstracts, vol. 95, No. 5, Aug. 3, 1981, p. 733.
"Catalytic synthesis of coumarin derivatives of beta-arrylamino ketones", Chemical Abstracts, vol. 70 No. 5, Feb. 3, 1969, p. 1974.
"Study of the heterogeneous catalytic acylation of phenols in the manufacture of coumarin and chromone" Chemical Abstracts, vol. 108, No. 17, Apr. 25, 1988, p. 723.

Affiliated with

Also associated with

Rating

Process for producing coumarin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing coumarin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing coumarin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2343202