Thiazolidine derivatives and their use

Details Thiazolidine derivatives and their use Thiazolidine derivatives and their use

1981-01-21

1983-06-07

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548183, C07D27704, A61K 31425

Patent

active

043871011

ABSTRACT:
A thiazolidine derivatives of the formula: ##STR1## wherein R is a phenyl group having 2 nuclear substituent groups selected from the group consisting of a lower alkyl having 1 to 6 carbon atoms, a lower alkoxy having 1 to 7 carbon atoms, hydroxyl and a carboxylic acyloxy having 1 to 4 carbon atoms, or a phenyl group having a methylenedioxy group in adjacent positions on its ring; R.sup.1 is H or an alkyl having 1 to 6 carbon atoms, or a physiologically acceptable salt thereof is a novel compound having the activity to control certain chronic symptoms due to diabetes, such as diabetic cataract, diabetic neuropathy and diabetic retinosis.

REFERENCES:
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patent: 3311655 (1967-03-01), Boileau et al.
patent: 3825553 (1974-07-01), Diamond et al.
patent: 4186129 (1980-01-01), Huth et al.
patent: 4340605 (1982-07-01), Kawamatsu et al.
patent: 4349683 (1982-09-01), Bigg
Burton et al., Jour. of Medicinal Chemistry, vol. 13, pp. 1009-1012, (1970).

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