Chemoprevention of electrophilic damage by mercaptopurine analog

Details Chemoprevention of electrophilic damage by mercaptopurine analog Chemoprevention of electrophilic damage by mercaptopurine analog

1992-03-04

1993-07-27

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3141

Patent

active

052311082

ABSTRACT:
Analogs of 6-mercaptopurine have been found to enhance the detoxification of various electrophilic toxicants in vivo, while having minimal cytotoxicity themselves. This property allows such compounds to act as scavengers for electrophilic toxicants, thereby preventing the cellular damage caused by such toxic agents.

REFERENCES:
patent: 2819198 (1958-01-01), Goohue
patent: 4400196 (1983-08-01), Albrecht
patent: 4594096 (1986-10-01), Albrecht
CA:104:2187f, Wright et al 1986.

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