Nucleic acids encoding cytokine synthesis inhibitory factor (int

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435695, 4351723, 4353201, 536 235, 536 2351, 935 22, 935 27, 935 55, 935 56, 530351, 930141, C12P 2102, C12N 1524, C07H 1512

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052310124

ABSTRACT:
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs) (now known as interleukin -10), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-.gamma..

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