Methods of detecting the presence of human herpesvirus-7 infecti

Details Methods of detecting the presence of human herpesvirus-7 infecti Methods of detecting the presence of human herpesvirus-7 infecti

1990-07-19

1993-07-27

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

4352351, 435 71, 435 75, 435810, 436511, 5303894, 5303883, C12Q 170, G01N 33571

Patent

active

052309975

ABSTRACT:
The present invention relates to a new human herpesvirus-7, proteins encoded in the genome of the virus, and antibodies specific for the virus and proteins. The virus was isolated from human peripheral blood mononuclear cells following incubation of the cells under conditions promoting T cell activation. Cultures of lymphocytes infected with the virus exhibited a cytopathic effect and electron microscopic analyses revealed a characteristic herpesvirus structure. The new virus is distinct from previously characterized human herpesviruses.
The invention also relates to bioassays for the diagnosis of human herpesvirus-7 and the detection of human herpesvirus-7 in a biological sample. It further relates to a vaccine for humans against human herpesvirus-7.

REFERENCES:
Lawrence et al., Journal of Virology, vol. 64, No. 1, Jan. 1990, pp. 287-299.

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