Synthetic immunoreglators, and methods of use and preparation

Details Synthetic immunoreglators, and methods of use and preparation Synthetic immunoreglators, and methods of use and preparation

1988-07-21

1996-01-02

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

514 54, A61K 4500, A61K 31715

Patent

active

054806429

ABSTRACT:
To regulate the immune response to an antigen, a subject with the antigen is injected with polyanionic polysaccharide derivative: (1) having a molecular weight of between 1,000 and 600,000; (2) selected to correspond to the antigen; (3) not being cytotoxic at an effective dosage; and (4) stimulating a cell-mediated immune response. For virus, as an example, mycodextran sulfate or pustulan sulfate may be used in sufficient quantities to stimulate cell-mediated immune responses without stimulating synthesis of gamma-E globulin and gamma-G globulins. The polyanionic polysaccharide derivative may be injected alone to stimulate cell-mediated immune responses to antigens in a diseased subject.

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