N-alkylation method of pyrazole

Details N-alkylation method of pyrazole N-alkylation method of pyrazole

1996-06-14

1998-01-06

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483771, C07D23112

Patent

active

057056560

ABSTRACT:
An N-alkylation method of pyrazole in which (III) is produced from (I) and (II), which is characterized by using a crystalline aluminosilicate or a crystalline aluminophosphate as a catalyst: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, alkyl, alkenyl or phenyl, R represents alkyl and Q represents hydrogen, alkyl or COOR. This is an industrially markedly useful method, because (III) can be obtained with a high yield under mild reaction conditions, and by-products including salts are not at all formed.

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Chemical Abstracts, AN-23466t, vol. 114, No. 3, 1991, S. Prasad, et al., "Mechanism of Aniline Alkylation with Methanol Over Aluminophosphate (ALP04-5)" & J. Mol. Catal, vol. 62, No. 2, 1990.

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