Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1993-07-13
1996-08-20
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
4352401, 4353201, 536 2351, 530399, C12P 2106, C12N 1518, C07H 1700, C07K 14475
Patent
active
055478565
ABSTRACT:
The invention concerns hepatocyte growth factor (HGF) amino acid sequence variants. The preferred variants are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form and/or contain a mutation within the protease domain of HGF.
REFERENCES:
patent: 4330528 (1982-05-01), Ruhenstroth-Bauer et al.
patent: 4341765 (1982-07-01), Ruhenstroth-Bauer et al.
patent: 4851341 (1989-07-01), Hopp et al.
patent: 5004805 (1991-04-01), Gohda et al.
patent: 5179078 (1993-01-01), Rollins et al.
patent: 5316921 (1994-05-01), Godowski
patent: 5328837 (1994-07-01), Godowski
Asami et al., "Purification and Characterization of Hepatocyte Growth Factor from Injured Liver of Carbon Tetrachloride-Treated Rats" J. Biochem. 109:8-13 (1991).
Bottaro et al., "Identification of the Hepatocyte Growth Factor Receptor as the c-met Proto-Oncogene Product" Science 251:802-804 (1991).
Chan et al., "Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript" Science 254:1382-1385 (1991).
Chang et al., "Cloning and Expression of a .gamma.-inferferon-inducible Gene in Monocytes: a New Member of a Cytokine Gene Family" International Immuno. 1(4):388-397 (1989).
Cooper et al., "Amplification and Overexpression of the MET Gene in Spontaneously Transformed NIH3T3 Mouse Fibroblasts" EMBO Journal 5(10):2623-2628 (1986).
Gak et al., "Processing of Hepatocyte Growth Factor to the Heterodimeric Form is Required for Biological Activity" FEBS Letters 311(1):17-21 (1992).
Giordano et al., "Tyrosine Kinase Receptor Indistinguishable from the C-Met Protein" Nature 339:155-156 (May 11, 1989).
Gohda et al., "Purification and Partial Charcterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure" J. Clin. Invest. 81:414-419 (1988).
Han et al., "Characterization of the DNF15S2 Locus on Human Chromosome 3: Identification of a Gene Coding for Four Kringle Domains with Homology to Hepatocyte Growth Factor" Biochemistry 30:9768-9780 (1991).
Igawa et al., "Hepatocyte Growth Factor is a Potent Mitogen for Cultured Rabbit Renal Tubular Epithelial Cells" Biochem. & Biophys. Res. Comm. 174(2):831-838 (Jan. 31, 1991).
Lindroos et al., "Hepatocyte Growth Factor (Hepatopoietin A) Rapidly Increases in Plasma before DNA Synthesis and Liver Regeneration Stimulated by Partial Hepatectomy and Carbon Tetrachloride Administration" Hepatol. 13:743-750 (1991).
Matsumoto et al., "Hepatocyte Growth Factor is a Potent Stimulator of Human Melanocyte DNA Synthesis and Growth" Biochem. & Biophys. Res. Comm. 176:45-51 (1991).
Michalopoulos et al., "Control of Hepatocyte Replication by Two Serum Factors" Cancer Research 44:4414-4419 (Oct. 1984).
Miyazawa et al., "An Alternatively Processed mRNA Generated from Human Hepatocyte Growth Factor Gene" European Journal of Biochemistry 197:15-22 (1991).
Miyazawa et al., "Molecular Cloning and Seqence Analysis of cDNA for Human Hepatocyte Growth Factor" Biochem. & Biophys. Res. Comm. 163:967-973 (1989).
Montesano et al., "Identification of a Fibroblast-Derived Epithelial Morphogen as Hepatocyte Growth Factor" Cell 67:901-908 (1991).
Nakamura et al., "Molecular Cloning and Expression of Human Hepatocyte Growth Factor" Nature 342:440-443 (1989).
Nakamura et al,, "Partial Purification and Characterization of Hepatocyte Growth Factor from Serum of Hepatectomized Rats" Biochem. & Biophys. Res. Comm. 122:1450-1459 (1984).
Nakamura et al., "Purification and Characterization of a Growth Factor from Rat Platelets for Mature Parenchymal Hepatocytes in Primary Cultures" Proc. Natl. Acad. Sci, USA 83:6489-6493 (1986).
Nakamura et al., "Purification and Subunit Structure of Hepatocyte Growth Factor from Rat Platelets" FEBS Letters 224:311-316 (1987).
Naldini et al., "Hepatocyte Growth Factor (HGF) Stimulates the Tyrosine Kinase Activity of the Receptor Encoded by the Proto-Oncogene c-MET" Oncogene 6:501-504 (1991).
Naldini et al., "Scatter Factor and Hepatocyte Growth Factor are Indistinguishable Ligands for the MET Receptor" EMBO Journal 10:2867-2878 (1991).
Okajima et al., "Primary Structure of Rat Hepatocyte Growth Factor and Induction of Its mRNA During Liver Regeneration Following Hepatic Injury" European Journal of Biochemistry 193:375-381 (1990).
Park et al., "Sequence of MET Protooncogene cDNA has Features Characteristic of the Tyrosine Kinase Family of Growth-Factor Receptors" Proc. Natl. Acad. Sci. USA 84:6379-6383 (1987).
Rubin et al., "A Broad-Spectrum Human Lung Fibroblast-Derived Mitogen is a Variant of Hepatocyte Growth Factor" Proc. Natl. Acad Sci, USA 88:415-419 (1991).
Russell et al., "Partial Characterization of a Hepatocyte Growth Factor From Rat Platelets" J. Cellular Physiology 119:183-192 (1984).
Seki et al., "Isolation and Expression of cDNA for Different Forms of Hepatocyte Growth Factor from Human Leukocyte" Biochem. and Biophys. Res. Commun. 172:321-327 (1990).
Shima et al., "Tumor Cytotoxic Factor/Hepatocyte Growth Factor from Human Fibroblasts: Cloning of Its cDNA, Purification and Characterization of Recombinant Protein" Biochem. & Biophys. Res. Comm. 180(2):1151-1158 (1991).
Stoker et al., "Scatter Factor is a Fibroblast-Derived Modulator of Epithelial Cell Mobility" Nature 327:239-242 (1987).
Tashiro et al., "Deduced Primary Structure of Rat Hepatocyte Growth Factor and Expression of the mRNA in Rat Tissues" Proc. Natl. Acad. Sci. USA 87:3200-3204 (1990).
Van Damme et al., "Structural and Functional Identification of Two Human, Tumor-derived Monocyte Chemotactic Proteins (MCP-2 and MCP-3) Belonging to the Chemokine Family" Journal of Experimental Medicine 176:59-65 (1992).
Weidner et al., "Scatter Factor: Molecular Characteristics and Effect on the Invasiveness of Epithelial Cells" Journal of Cell Biology 111:2097-2108 (1990).
Wiman, "Primary Structure of the B-Chain of Human Plasmin" European Journal of Biochemistry 76:129-137 (1977).
Matsumoto et al 1991 Biochem Biophys Res. Commun. 181:691-699.
Seki et al 1991 Gene 102:213-219.
Okigaki et al 1992 Biochemistry 31:9555-9561.
Naka et al 1992 J Biol. Chem 267:20114-20119.
Lokker et al 1992 EMBO J. 11:2503-2510.
Mark et al 1992 J. Biol. Chem 267:26166-26171.
Godowski Paul J.
Lokker Natalie A.
Mark Melanie R.
Carlson K. Cochrane
Genentech Inc.
Marschang Diane L.
Wax Robert A.
LandOfFree
Hepatocyte growth factor variants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hepatocyte growth factor variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatocyte growth factor variants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2330121