Methods of producing antigen forks

Details Methods of producing antigen forks Methods of producing antigen forks

1995-03-01

1998-01-06

Eisenschenk, Frank C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303882, 53038822, 5303888, 53038885, 43524026, 43524027, C07K 1646, C12N 512

Patent

active

057056145

ABSTRACT:
The present invention relates to a class of molecules called "antigen forks" that inhibit cell growth. These antigen forks possess separate binding elements for two different cell surface antigens and are believed to heterologously crosslink the antigens by binding to them. The two antigens recognized by an antigen fork differ in at least one cellular functional quality, but are simultaneously expressed on the surface of at least one cell type targeted for killing or growth inhibition. The present invention also relates to a method of assay to determine which antibodies may be useful in the preparation of antigen forks.

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Debrin et al., Oncogene (1988) 2:387-394.
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Yu, et al., Cancer Research (1990) 50:3231-3238.
Ring et al., Canc. Immunol. Immunother., 1994, 39:41.

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