Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-12-07
1997-05-27
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 4351723, 435325, 435348, 435369, 435358, 536 235, 536 243, 536 245, 536 2431, 935 11, 935 22, 935 66, C07K 1452, C12N 1519
Patent
active
056331495
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
REFERENCES:
Uhlmann et al. "Antisense Oligonucleotides: a New Therapeutic Principle," Chemical Reviews, vol. 90, No. 4, pp. 554-584 (Jun. 1990).
Cotten et al., "Ribozyme Mediated Destruction of RNA in vivo," The EMBO Journal, vol. 8, No. 12, pp. 3861-3866 (1989).
Ledley, "Clinical Consideration in the Design of Protocols for Somatic Gene Therapy," Human Gene Therapy, vol. 2, pp. 77-82 (1991).
Anderson, "Prospects for Human Gene Therapy," Science, vol. 226, pp. 401-409 (Oct. 1984).
Opdenakker et al., "The Human MCP-3 Gene (SCYA7): Cloning, Sequence Analysis, and Assignment to the C--C Chemokine Gene Cluster on Chromosome 17q11.2-q12," Genomics, vol. 21, pp. 403-408 (May 1994).
Jan Vilcek, et al., Immunology of Cytokines, The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 1, pp. 1-17.
Alan R. Shaw, Molecular Biology of Cytokines, The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 2, pp. 20-46.
Jacques Banchereau, Interleukin-4, The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 6, pp. 120-148.
Thomas J. Schall, The Chemokines, The Cyotkine Handbook, Academic Press, 1994, Sep. 19-20, 1994, Second Edition, pp. 180-272.
Diamond et al. (1993) Journal of Biol. Chem. vol. 268. No. 20 pp. 15185-15192.
Guegler Karl J.
Hawkins Phillip R.
Seilhamer Jeffrey J.
Wilde Craig G.
Incyte Pharmaceuticals Inc.
Luther Barbara J.
Mertz Prema
Ulm John
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