Reaction vessel for immunological analysis of aerosols

Details Reaction vessel for immunological analysis of aerosols Reaction vessel for immunological analysis of aerosols

1994-12-22

1997-05-27

Spiegel, Carol A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 79, 435 793, 435961, 435963, 435970, 436518, 436528, 436530, 436 32, 436178, 436181, 436810, 422 58, 422 83, G01N 3353

Patent

active

056331401

ABSTRACT:
A unitary collection and displacement immunoassay device for determining a toxic substance adhered to aerosols in the air is provided. The device comprises an elongated body having proximal and distal ends and encloses a space defining a collection chamber, a reaction chamber and a measurement chamber, each chamber separated by a liquid flow barrier which delays liquid transport between chambers until a vacuum source is applied to the distal end of the test device to pull liquid into the next chamber. The collection chamber contains a solution for solubilizing the toxic substance from the aerosols and a semi-permeable means for separating the solubilized toxic substance from the aerosols. The reaction chamber contains a labelled immunoreactant bound to a solid phase carrier material. The labelled reagent can be displaced by the solubilized toxic substance. The measurement chamber contains a color generating system which reacts with displaced labelled reagent to produce a colored product in proportion to the concentration of the toxic substance.

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"Dr ager-R ohrchen Handbuch", published by Dr agerwerk Aktiengesellschaft L ubeck, 1991. No Translation.
"The Measurement of Antibody Affinity: a Comparison of Five Techniques Utilizing a Panel of Monoclonal Anti-DNP Antibodies and the Effect of High Affinity Antibody on the Measurement of Low Affinity Antibody" by C. Stanley et al, Journal of Immunological Methods, vol. 54, (1983), pp. 119 to 132.

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