Bis-naphthalimides containing amino-acid derived linkers as anti

Details Bis-naphthalimides containing amino-acid derived linkers as anti Bis-naphthalimides containing amino-acid derived linkers as anti

1991-12-11

1993-04-27

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 99, C07D22114, A61K 31435

Patent

active

052062490

ABSTRACT:
This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione], processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat cancer in mammals.

REFERENCES:
patent: 4665071 (1987-05-01), Zee-Cheng et al.
patent: 4874863 (1989-10-01), Brana et al.
patent: 4919848 (1990-04-01), Harnisch
patent: 5086059 (1992-02-01), Ardecky et al.

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