Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1994-03-31
1997-05-27
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424435, 514 54, A61K 31715, A01N 4304
Patent
active
056330030
ABSTRACT:
The subject invention is directed to the treatment of respiratory disorders by intratracheal administration of an effective amount of hyaluronic acid. Respiratory disorders include emphysema, chronic bronchitis, asthma, pulmonary edema, acute respiratory distress syndrome, bronchopulmonary dysplasia, pulmonary fibrosis, and pulmonary atelectasis. The treatment is intended for a variety of mammals, such as premature neonates to adult humans. Administration of hyaluronic acid may be performed by aerosol, which can be generated by a nebulizer, or by instillation. The hyaluronic acid may be administered alone, or with a carrier such as saline solution, DMSO, an alcohol or water. It may be isolated from a natural source such as a bovine or rooster. The effective daily amount of hyaluronic acid is from about 10 .mu.g/kg to about 1 mg/kg of body weight.
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Karlinsky, J.B. (Apr. 1978) "Glycosaminoglycans: Amounts and distribution in Experimental Pulmonary Fibrosis and Emphysema", Am. Rev. Resp. Dis. 117:356 (Exhibit 9).
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Azpuru Carlos
White John P.
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