Hydrogenation process for the formation of 3,4-dihydro HMG-CoA r

Details Hydrogenation process for the formation of 3,4-dihydro HMG-CoA r Hydrogenation process for the formation of 3,4-dihydro HMG-CoA r

1987-09-03

1989-05-16

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, C07D30930, C07F 718

Patent

active

048311650

ABSTRACT:
A novel hydrogenation process using a homogenous rhodium catalyst for selectively reducing the 3,4 double bond in the polyhydronaphthyl ring of lovastatin, simvastatin or C-8-acyl or C-6-substituted analogs thereof is disclosed.

REFERENCES:
patent: 4351844 (1982-09-01), Patchett et al.
Smith et al., "Homogeneous Catalytic, etc", TL (7) 525 (1970).
Biellmann et al., "Homogeneous Phase, etc", CA 66: 104500s.
Kuo et al., J. Org. Chem., 48, 1991 (1983).

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