Process for the preparation of methyltrifluoroacetate

Details Process for the preparation of methyltrifluoroacetate Process for the preparation of methyltrifluoroacetate

1986-06-12

1988-03-08

Moyer, Donald B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

203 61, 203 66, 203 82, 203DIG6, C07C 6963, B01D 334

Patent

active

047300825

ABSTRACT:
A process for the preparation of methyltrifluoroacetate. Trifluoroacetic acid is contacted with an excess of methanol and distilled to form a methyltrifluoroacetate/methanol azeotrope. The azeotrope is contacted with trifluoroacetic acid in the presence of a catalytic quantity of a strong acid followed by distillation to obtain methyltrifluoroacetate. The methyltrifluoroacetate can be used as a synthesis intermediate in the pharmaceutical industry.

REFERENCES:
patent: 2649407 (1953-08-01), Harrison et al.
patent: 4250328 (1981-02-01), Fujita et al.
patent: 4435595 (1984-03-01), Agreda et al.
Hagen, Miller, et al., 47, J. of Organic Chemistry, 1345-47, (1982).
Moffat & Hunt, 79, J. of the American Chemical Society, 54, (1957).
Moffat & Hunt, 81, J. of the American Chemical Society, 2082-86, (1959).

Affiliated with

Also associated with

Rating

Process for the preparation of methyltrifluoroacetate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of methyltrifluoroacetate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of methyltrifluoroacetate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-232173