N-substituted amino acid derivatives

Details N-substituted amino acid derivatives N-substituted amino acid derivatives

1983-11-14

1985-08-13

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

548497, C07C10120

Patent

active

045351775

ABSTRACT:
Optical isomeric compounds having the general formula ##STR1## are prepared by: reacting by catalytic hydrogenation a compound of the formula ##STR2## with a compound of the formula ##STR3## wherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined herein, to form a mixture of isomers in a ratio of L(S)L(S)>D(R)L(S); and recovering the (S,S) diastereomer by selectively precipitating an acid salt of the (S,S) ester from the solution.

REFERENCES:
patent: 2520042 (1950-08-01), Lisk et al.
patent: 3778463 (1973-12-01), Gronowitz et al.
patent: 3894051 (1975-07-01), Suh
patent: 4350704 (1982-09-01), Hoefle et al.
Yamada et al., "Asymmetric Transamination from Amino Acids (I)", Tetrahedron Letters, 1976, (13), pp. 997-1000.

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