Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-m

Details Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-m Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-m

1983-11-01

1985-08-13

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48908

Patent

active

045351570

ABSTRACT:
An improved Wittig reaction for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone from naloxone and naltrexone utilizing an alkoxide base in an ethereal solvent.

REFERENCES:
patent: 3814768 (1974-06-01), Fishman
patent: 4322426 (1982-03-01), Hermann et al.
Hahn, et al., J. Med. Chem., vol. 18, No. 3, pp. 259-262 (1975).

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