Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-

Details Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2- Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-

1983-08-17

1985-08-13

Daus:, Donald

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514267, 544251, 544278, A61K 31505, C07D51304

Patent

active

045350817

ABSTRACT:
Antiallergy and antiulcer agents having the formula (I), ##STR1## and their pharmaceutically acceptable salts, wherein R.sub.1 and R.sub.2 taken separately are each hydrogen or lower alkyl; and R.sub.1 and R.sub.2 taken together are alkylene of 3-9 carbon atoms or phenylalkylene of 9-11 carbon atoms, with the proviso that the ring so formed is between 5- and 8-membered; acids of the formula (II), ##STR2## wherein R.sub.1 and R.sub.2 are as defined above and R.sub.3 is hydrogen, which are useful as intermediates for compounds of the formula (I), but in many instances also possess the same useful biological activity as do formula I compounds; and intermediates of the formula II wherein R.sub.1 and R.sub.2 are defined as above, and R.sub.3 is alkyl of 1 to 4 carbon atoms, carbalkoxy of 2 to 5 carbon atoms, carbophenoxy or carbobenzoxy, are also described.

REFERENCES:
patent: 3538086 (1970-11-01), Mair et al.
patent: 3694441 (1972-09-01), Dunwell et al.
patent: 3876639 (1975-04-01), Baetz
patent: 4041163 (1977-08-01), Bindra et al.
patent: 4232024 (1980-11-01), Winter et al.
patent: 4414388 (1983-11-01), Kadin
patent: 4443451 (1984-04-01), Kennis et al.
Ohta et al., Chemical Abstracts, vol. 49, 10931g, (1955).
Yamane et al., Chemical Abstracts, vol. 71, 61274e, (1969).
Dunwell et al., J. Chem Soc., 1971, 2094-2097.

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