Nucleic acids encoding cytokine synthesis inhibitory factor (Int

Details Nucleic acids encoding cytokine synthesis inhibitory factor (Int Nucleic acids encoding cytokine synthesis inhibitory factor (Int

1995-06-05

2000-01-25

Mertz, Prema

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 2431, 530351, 930141, C12N 1524, C07K 1454

Patent

active

060180366

ABSTRACT:
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-.gamma..

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