Metalloproteinase inhibitors

Details Metalloproteinase inhibitors Metalloproteinase inhibitors

1998-12-23

2000-01-25

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

548477, 562431, 562623, C07C32341, A61K 3116

Patent

active

060178892

ABSTRACT:
Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a --CO.sub.2 H or --CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption. ##STR1##

REFERENCES:
patent: 3468936 (1969-09-01), van der Burg
patent: 4996358 (1991-02-01), Handa et al.
patent: 5183900 (1993-02-01), Galardy et al.
patent: 5300674 (1994-04-01), Crimmin et al.
patent: 5304549 (1994-04-01), Broadhurst et al.

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