Pyrimidine 2,4-dioxamate compounds and pharmaceutical compositio

Details Pyrimidine 2,4-dioxamate compounds and pharmaceutical compositio Pyrimidine 2,4-dioxamate compounds and pharmaceutical compositio

1987-04-03

1988-03-08

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514233, 514234, 514236, 514252, 514272, 514275, 540601, 540467, 540470, 540481, 544122, 544295, 544320, 544321, 544323, A61K 31505, A61K 31535, C07D23948, C07D41304

Patent

active

047299959

ABSTRACT:
Novel pyrimidine compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.1 ' are each hydrogen atom, a lower alkyl, benzyl, an alkali metal, or ammonium; R.sub.2 is hydrogen atom, a halogen atom, a lower alkyl, a lower alkoxy, an aryl, a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each hydrogen atom, a lower alkyl, or an aryl), or a group of the formula: ##STR3## [wherein R.sub.5 and R.sub.6 are each an alkylene having 1 to 3 carbon atoms, and X is oxygen atom, methylene, or a group of the formula: >N-Y (wherein Y is hydrogen atom, a lower alkyl, benzyl, or an aryl)], which have excellent antiallergic activities and are useful for the prophylaxis and treatment of various allergic diseases, and a pharmaceutical composition containing said pyrimidine compound as an active ingredient.

REFERENCES:
Bazzano, International Publication Number WO86/00616, Jan. 30, 1986.

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