Human N-acetyl transferase

Details Human N-acetyl transferase Human N-acetyl transferase

1998-08-04

2000-01-25

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4241391, 514 12, 514 23, 514 44, 530350, 5303879, 536 111, 536 231, C12N 911

Patent

active

060177446

ABSTRACT:
The invention provides a human N-acetyl transferase (NACTH) and polynucleotides which identify and encode NACTH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NACTH.

REFERENCES:
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Park, E.C. et al., "ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity", EMBO J., 11: 2087-2093 (1992).
Wolffe, A.P., "Histone Deacetylase: A Regulator of Transcription", Science, 272: 371-372 (1996).
Van Lint, C. et al., "Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation", EMBO J., 15: 1112-1120 (1996).
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Kleff, S. et al., "Identification of a Gene Encoding a Yeast Histone H4 Acetyltransferase", J. Biol. Chem., 270: 24674-24677 (1995).

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