Acyloxymethyl esters of bisphosphonic acids as bone resorption i

Details Acyloxymethyl esters of bisphosphonic acids as bone resorption i Acyloxymethyl esters of bisphosphonic acids as bone resorption i

1990-07-12

1993-07-13

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

558155, 558156, 558162, 558163, 558203, 544337, 514 86, 514 89, 514 79, 514 90, 568 10, 546 22, 548413, 554 78, 554 84, C07F 902

Patent

active

052275060

ABSTRACT:
The invention relates to acyloxymethyl esters of bisphosphonic acids, halo-bisphosphonic acids and hydroxy-bisphosphonic acids which exhibit oral bioavailability and are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.

REFERENCES:
patent: 3584125 (1971-06-01), Francis et al.
patent: 3962432 (1976-06-01), Schmidt-Dunker
patent: 4054598 (1977-10-01), Blum et al.
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4473560 (1984-09-01), Biere et al.
patent: 4478763 (1984-10-01), McKenna
patent: 4621077 (1986-11-01), Rosini et al.
patent: 4719203 (1988-01-01), Basies et al.
patent: 4732998 (1988-03-01), Binderup
Srivastva, et al, Biorganic Chemistry, vol. 12, 1984 pp. 118-129.
Farquhar et al, Journal of Pharmaceutical Sciences, vol. 72, #3, 1983, pp. 324-325.
Chemical Abstracts, vol. 109, .andgate.24, p. 76, 1988 222488y.
Mortan et al., Br. J. Cancer, 58, 556-557 (1988).

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