Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1983-10-03
1986-08-26
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
A61K 3128
Patent
active
046083871
ABSTRACT:
This disclosure relates to the use of cytostatically active cyclopentadienyl metal-acido complexes for the treatment of transplanted tumor and pharmaceutical compositions containing said complexes. The organometallic compounds employed in the invention have the general formula: ##STR1## wherein M is Ti, Zr, Hf, V, Nb, Ta, Mo or W, Cp and Cp' are, e.g., cyclopentadienyl or substituted cyclopentadienyl radicals, Z is an optional straight-chain or branched bridging group having 1 to 3 C, Si or Ge atoms in the bridging chain and X and X' are, e.g., halogen, cyanate, isocyanate, thiocyanate, isothiocyanate, azide or phenylacetylide.
REFERENCES:
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patent: 3080305 (1963-03-01), Gorsich
patent: 3152157 (1964-10-01), Shapiro et al.
patent: 3161629 (1964-12-01), Gorsich
Feld et al., The Organic Chemistry of Titanium, Washington-Butterworths, 1965, pp. 12-14.
Wailes et al., Organometallic Chemistry of Titanium, Zirconium, Hafnium, Academic Press, N.Y., N.Y., 1974, pp. 52 and 53.
Kopf Hartmut
Kopf-Maier Petra
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