Antifungal composition and method employing pyridinium compounds

Details Antifungal composition and method employing pyridinium compounds Antifungal composition and method employing pyridinium compounds

1984-09-05

1986-08-26

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514222, 514227, 514238, 514240, 514252, 514343, 514351, 514352, 514357, 544 60, 544125, 544360, 546193, 546194, 546281, 546300, 546304, 546312, 546329, 546334, A01N 4340, A01N 4384

Patent

active

046083790

ABSTRACT:
Compounds containing a cation of formula Ia ##STR1## and a pharmaceutically acceptable anion are anti-fungal agents. In formula Ia and Ib R.sub.1 is alkyl of at least 3 carbon atoms or aralkyl; R.sub.2 and R.sub.5 are hydrogen, lower alkyl, lower alkoxy, halogen or nitro; R.sub.6 and R.sub.7, when separate, are lower alkyl or aryl(lower)alkyl or, when joined together, are --(CH.sub.2).sub.2 --A--(CH.sub.2).sub.2 -- (where A is --(CH.sub.2).sub.n --, O, S or NR.sub.8 where n is O, 1 or 2 and R.sub.8 is lower alkyl) or a mono- or di-(lower alkyl) substitution product thereof.

REFERENCES:
patent: 2255077 (1941-09-01), Middleton
patent: 2686784 (1954-08-01), Finkelstein et al.
Chemical Abstracts, 95:44740g (1981) [Beecken, Ger. Offen. 2,932,092, 2/26/81].
Chemical Abstracts, 96:81205 (1982) [Barni et al., Helv. Chim. Acta 1981, 64(6), 1943-8].
Phillips, A., J. Org. Chem., 12, 333 (1947).
Mills, W., et al., J. Chem. Soc., 121, 946 (1922).
Clemo, G., et al., J. Chem. Soc., 1938, pp. 1454-1455.
Williams, J., et al., J. Org. Chem., 28, 388 (1963).
Doja, M., et al., J. Ind. Chem. Soc., 24, 301-306 (1947).
Doja, M., et al., J. Ind. Chem. Soc., 19, 125-129, 377-384 (1942).
Doja, M., et al., J. Ind. Chem. Soc., 23, 117-120 (1946).
Brooker, L., et al., J. Am. Chem. Soc., 67, 1875 (1945).
Foley, G., et al., Ann. N.Y. Acad. Sci., 76, 413-441 (1958).
Kolomoitsev, L., et al., Mikrobiol. Zh. Akad. Nauk. Ukr. SSR., 25(5), 58-67 (1963).
Bahner, C., et al., J. Am. Chem. Soc., 75, 4838 (1953).
Bahner, C., et al., J. Am. Chem. Soc., 73, 3407 (1951).

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