Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1983-09-15
1986-08-26
Marantz, Sidney
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
435 7, 435 23, 436520, 436521, 436522, 436809, G01N 33555
Patent
active
046082468
ABSTRACT:
A method of forward blood grouping is presented wherein known antibodies are attached to a solid surface and the red blood cells presented for immunological reaction are activated with a proteolytic enzyme. A reverse blood grouping procedure utilizes synthetic or purified antigens which are attached directly to a solid surface. The surface is then contacted with an unknown blood component to permit antibodies to undergo immunological reaction with the previously attached antigens. A solution of red blood cells is used as the indicator. A method of performing a major crossmatch utilizes anti-human immunoglobulin that is attached to a solid surface which is then contacted by the two blood components to permit an antigen-antibody interaction of red blood cells and antibodies. The antibody sensitized cells will immunologically adhere to the solid phase. In an alternative major crossmatch procedure, a binder is used to attach red blood cell membranes from a blood donor and the serum from a recipient is allowed to undergo an immune reaction with these membranes on the solid surface. Antibody screening and antibody identification are carried out by attaching known antigen carrying cells to a solid surface. The solid surface is contacted with the unknown solution which will undergo an immune reaction to the extent antibodies specific to the previously adhered antigens are present. Red blood cells or synthetic particles coated with anti-human immunoglobulins are used as the indicator mechanism.
REFERENCES:
patent: 3904367 (1975-09-01), Golibersuch
patent: 3987159 (1976-10-01), Spona
patent: 4252538 (1981-02-01), Barr
patent: 4275053 (1981-06-01), Rosenfield
patent: 4328183 (1982-05-01), Rosenfield
patent: 4371515 (1983-02-01), Chu
patent: 4403037 (1983-09-01), Coates
"Immunoassays for the 80s", A. Voller et al., eds., Chapter 3 by R. R. A. Coombs, University Park Press, Baltimore, Md., 1981.
Bayer William L.
Beck Malcolm L.
Coenen William M.
Plapp Frederick V.
Sinor Lyle T.
Immucor, Inc.
Marantz Sidney
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