Proteinase inhibitor

Details Proteinase inhibitor Proteinase inhibitor

1994-10-05

1996-04-23

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548477, 554 56, 556420, 560159, 564 94, 564164, C07C23300

Patent

active

055105319

ABSTRACT:
A Novel N-substituted peptidyl compound represented by the general formula (1): ##STR1## where R.sub.1 is a straight-chained or branched acyl group having 2-10 carbon atoms, a branched, cyclic or bridged cyclic alkyloxycarbonyl group having 4-15 carbon atoms; a benzyloxycarbonyl group which is unsubstituted or substituted with a halogen atom, nitro group or methoxy group; a 2,2,2-trichloroethyloxycarbonyl group, a 2-(trimethylsilyl)ethyloxycarbonyl group, a p-toluensulfonyl group, an o-nitrophenylsulfenyl group, a diphenylphosphonothioyl group, a triphenylmethyl group, a 2-benzoyl-1-methylvinyl group;
R.sub.2 is a hydrogen atom or when taken together with R.sub.1, may form a phthaloyl group;
R.sub.3 is an isobutyl group, a n-butyl group or an isopropyl group;
R.sub.4 is a butyl group, and
R.sub.5 is a hydrogen atom;
provided that R.sub.1 can be an unsubstituted benzyloxycarbonyl group only when R.sub.3 is a n-butyl group.

REFERENCES:
patent: 3933786 (1976-01-01), Peter
patent: 5081284 (1992-01-01), Higuchi
patent: 5162550 (1992-11-01), Zink
"Hackh's Chemical Dictionary," 4th Ed p. 16 (1969).

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