Human IL-2 receptor .gamma. chain molecule

Details Human IL-2 receptor .gamma. chain molecule Human IL-2 receptor .gamma. chain molecule

1993-04-22

1996-04-23

Jones, W. Gary

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4353201, 4352523, 43524026, 536 2352, 536 231, 536 235, 935 6, 935 11, 935 22, 935 23, 935 24, 935 66, 935 70, 935 72, 935 73, C12N 500, C12N 1500, C07H 2104

Patent

active

055102590

ABSTRACT:
The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.
Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.

REFERENCES:
Takeshita et al., Science, vol. 257, pp. 379-382, 17 Jul. 1992.
Lymphokine Research, vol. 9, No. 4, pp. 539-542, 1990, K. Sugamura, et al., "IL-2-Induced Signal Transduction: Involvement of Tyrosine Kinase and IL-2 Receptor .gamma. Chain".
Science, vol. 257, pp. 379-382, Jul. 17, 1992, T. Takeshita, et al., "Cloning of the .gamma. Chain of the Human IL-2 Receptor".
The Journal of Immunology, vol. 148, No. 7, pp. 2154-2158, Apr. 1, 1992, T. Takeshita, et al., "An Associated Molecule, p. 64, with IL-2 Recteptor .beta. Chain. Its Possible Involvement in the Formation of the Functional Intermediate-Affinity IL-2 Receptor Complex".
The Embo Journal, vol. 9, No. 12, pp. 3899-3905, 1990, S. M. Zurawski, et al., "Partial Agonist/Antagonist Mouse Interleukin-2 Proteins Indicate that a Third Component of the Receptor Complex Functions in Signal Transduction".

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