Fluorescence detection of cell proliferation

Details Fluorescence detection of cell proliferation Fluorescence detection of cell proliferation

1994-04-05

1995-10-10

Sykes, Angela D.

Surgery

Truss

Pad

A61B 600

Patent

active

054562600

ABSTRACT:
The method of the present invention is directed at detecting non-invasively and in vivo the rate of proliferation of epithelial cells in a human patient. The method is based on determining the optical spectra, preferably the fluorescence excitation spectra, from affected and non-affected areas of epithelial cells, and then comparing the two spectra from these regions. In particular, applicants have discovered that when human or animal skin is irradiated with light centered near 295 nm, fluorescence having a distinct maximum near 360 nm is induced.

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Tang et al. "Pulsed and cw laser fluorescence spectra from cancerous, normal, and chemically treated normal human breast and lung tissues," Applied Optics, 28:2337-2342, 1989.

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