Process for preparing stable oxygen transferable emulsion

Details Process for preparing stable oxygen transferable emulsion Process for preparing stable oxygen transferable emulsion

1974-07-02

1976-11-23

Lovering, Richard D.

Compositions

Preservative agents

Anti-corrosion

252314, 252356, 424352, B01J 1300

Patent

active

039935817

ABSTRACT:
Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.

REFERENCES:
patent: 1500670 (1924-07-01), DeGroote
patent: 1786249 (1930-12-01), Kirschbraun
patent: 2269529 (1942-01-01), Goldsmith
patent: 3232765 (1966-02-01), Rosenthal et al.
patent: 3778381 (1973-12-01), Rosano et al.
patent: 3823091 (1974-07-01), Samejima et al.
patent: 3911138 (1975-10-01), Clark, Jr.

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