Chemically modified endotoxin immunizing agent

Details Chemically modified endotoxin immunizing agent Chemically modified endotoxin immunizing agent

1974-05-09

1977-11-08

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

260112R, 424 88, 424 92, 424 94, 424180, 536 1, 536119, C08B 3700

Patent

active

040576850

ABSTRACT:
A bacterial endotoxin lipopolysaccharide of reduced toxicity covalently coupled to a protein antigen exhibits enhanced adjuvant effects. The coupling was affected by reaction with haloacylhalide. Lipopolysaccharide acylated with an anhydride of a dibasic acid is detoxified; in combination with endotoxin polysaccharide covalently coupled to protein antigen it developed synergistic immunogenic effects.

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patent: 3459733 (1969-08-01), Byrd et al.
patent: 3600378 (1971-08-01), Marsh et al.
patent: 3655645 (1972-04-01), Jacques
patent: 3697652 (1972-10-01), Rovati et al.
patent: 3879376 (1975-04-01), Vanlerberghe et al.

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