Process for the preparation of a salt of 1-(.gamma.-halopropyl)-

Details Process for the preparation of a salt of 1-(.gamma.-halopropyl)- Process for the preparation of a salt of 1-(.gamma.-halopropyl)-

1983-08-02

1986-01-21

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 86, 546 87, C07D47104

Patent

active

045658706

ABSTRACT:
Salts of 1,2,3,4-tetrahydro-.beta.-carbolines of the formula I ##STR1## where R is hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or trifluoromethyl, x is halogen and n is an integer from 2 to 5, and their preparation are described. The compounds are intermediates for the preparation of pharmacologically active substances.

REFERENCES:
patent: 2786059 (1957-03-01), Horlein
patent: 3304309 (1967-02-01), Shavel et al.
Chem. Abstracts, vol. 65, No. 3, p. 3844-c-e, Aug. 1, 1966.
Groves et al., Chem. Abstracts, vol. 46, No. 19, pp. 9569e-9571-d, Oct. 10, 1952.
Roger Adams, Ed., Organic Reactions, vol. VI, Chapter 3, "The Pictet-Spengler Synthesis of Tetrahydroisoquinolines and Related Compounds", (1951), pp. 151-187.
A. R. Katritsky, Ed., Advances in Heterocyclic Chemistry, vol. 3, "The Carbolines, III, Synthesis, A. Tetrahydrocarbolines", (1964), pp. 83-85.

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