Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1984-05-11
1986-01-21
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 56, 514110, 514256, 514288, 514554, 514708, 514731, 514936, A61K 31715, A61K 31725, A61K 3166, A61K 31505
Patent
active
045658064
ABSTRACT:
The invention concerns a composition, i.e., a multifunctional medically active agent for rational therapy of malignant (cancerous) diseases based on cause-and-effect relationship. The new composition according to the invention contains dimethylsulfoxide, DMSO, or sulfolan, preferably DMSO, in combination with a therapeutically effective amount of at least one cytostatic agent. The invention also concerns a method for treatment of malignant (cancerous) conditions in man comprising local or systemic administration thereto of an effective dosage of the composition according to the invention.
The invention surprisingly provides a composition, as well as a method of treatment, allowing rational specific or selective carcinostatic-carcinocidic therapy. This therapy-form aims at the intracytoplasmic 3-dimensional cytoskeleton (differentiation organelle) that is specifically changed in the malignant cells, as well as at the targets responsible for karyokinesis and cytokinesis.
REFERENCES:
Hill, "A Review of Cyclophosphamide", C. Thomas Pub. Chapt. 9., pp. 242-273, 1975.
Crethman et al., The Pharmacological Basis of Therapy, 6th ed., McMillan Inc., p. 1364, 1980.
Cecil Textbook of Medicine, 1979, pp. 1931, 1932, 1934, 1935 and 1936.
Setala, A Rational Anti-Cancer Therapy Experimental Study in Mice, Med. Sci., 9:1117-1118, 1981.
K. Setala, Med. Hypothesis, 8:207-230, 1982.
Warren et al., "Potentiation of Anti Neoplastic Compounds, NY Acad. Sci. 243:194-208, 1975.
Meyers Albert T.
Rollins Jr. John W.
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