Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-07-02
1993-08-31
Friedman, S. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 31205
Patent
active
052409619
ABSTRACT:
Methods of treating reduced insulin-like growth factor levels and bone loss associated with aging which include administering L-carnitine and/or its precursors thereof are disclosed. Such administration results in increased serum insulin-like growth factor-1 and osteocalcin levels.
REFERENCES:
patent: 4382092 (1983-05-01), Cavazza
patent: 5030458 (1991-07-01), Shug et al.
patent: 5104864 (1992-04-01), DeLuca et al.
Marcus, "Clinical Uses of Growth Hormone in Adult," Am. Soc. for Bone and Mineral Research, Clinical Day, San Diego, Calif., Aug. 28, 1991.
J. S. Johansen et al., "Insulin Like Growth Factor-1 Stimulates the Secretion of Bone GLA Protein but not the Gene Expression in Normal Adult Human Osteoblast Like Cells," Am. Soc. Bone and Mineral Res. Meeting in San Diego, Calif., Aug. 24-27, 1991. (Abstract only).
P. Ammann et al., "Chronic Infusion of IGF-1 Increases Bone Mineral Density (BMD) Evaluated Sequentially by Dual Energy X-Ray Absorptiometry (DXA) in Ovariectomized (OVX) Osteopenic Rats," Am. Soc. Bone and Mineral Res. Meeting in San Diego, Calif., Aug. 24-27, 1991. (Abstract only).
D. N. Kalu et al., "Insulin-Like Growth Factor-1 Partially Prevents Ovariectomy-Induced Bone Loss: A Comparative Study with Human Parathyroid Hormone (1-38)," Am. Soc. Bone and Mineral Res. Meeting in San Diego, Calif., Aug. 24-27, 1991. (Abstract only).
K. Mueller et al., "Insulin-Like Growth Factor-1 Increases Trabecular Bone Mass in the Ovariectomized Rat," Am. Soc. Bone and Mineral Res. Meeting in San Diego, Calif., Aug. 24-27, 1991. (Abstract only).
S. Ljunghall et al., "Is Circulating IGF-1 a Determinant for Male Osteoporosis?" Am. Soc. Bone and Mineral Res. Meeting in San Diego, Calif., Aug. 24-27, 1991. (Abstract only).
Berne, Robert, "The Endocrine System," Physiology, 2nd ed., (1988) pp. 878-879.
Chenu et al., Bone, vol. 11 (1990) pp. 81-86.
Hock et al., Endocrinol., vol. 122 (1988) pp. 254-260.
Pun et al., Bone, vol. 11 (1990) pp. 397-400.
"Diabetes Mellitus" pp. 1-12, Scientific American Medical Information Text, Eds. E. Rubinstein and D. Fedman, Scientific American Soc. (1992).
Hansford et al., Mechanisms of Aging and Dev., vol. 19 (1982) pp. 191-201.
Winter et al., Am. J. Dis. Child., vol. 141 (1987) pp. 660-665.
Nutr. Rev., vol. 36 (1978) pp. 305-309.
Chen et al., Can. J. Chem., vol. 54 (1976) pp. 3310-3311.
Welling et al., Int. J. Clin. Pharm. Biopharm., vol. 17 (1979) pp. 56-60.
Parvin et al., Anal. Biochem., vol. 79 (1977) pp. 190-201.
Grundberg et al., Meth. Enzymology, vol. 107 (1984) 516-544.
"Normal Carnitine Levels in Body Fluids and Tissues," Metabolic Analysis Labs, Inc., Madison, Wis.
Power et al., "Osteocalcin Concentrations in Plasma Prepared with Different Anticoagulants," Clin. Chem., vol. 37 (1991) pp. 281-284.
Vance, "Growth Hormone for the Elderly?" New England Journal of Medicine, vol. 323 (1990) pp. 52-54.
Rudman et al., New England Journal of Medicine, vol. 323 (1990) pp. 1-5.
Salomon et al., N. Engl. J. Med., vol. 321 (1989) pp. 1797-1803.
Cuneo et al., J. Appl. Physiol., vol. 70 (1991) pp. 688-700.
Marcus et al., J. Clin. Endocrinol. Metab., vol. 70 (1990) pp. 519-527.
Brixen et al., J. Bone Min. Res., vol. 5 (1990) pp. 609-618. (Abstract only.).
Stracke et al., Acta Endocrinol., vol. 107 (1984) pp. 16-24.
Friedman S. J.
Jarvis William
LandOfFree
Method of treating reduced insulin-like growth factor and bone l does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating reduced insulin-like growth factor and bone l, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating reduced insulin-like growth factor and bone l will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2297662