Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-11-05
1993-08-31
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546267, 546175, 546176, 546152, C07D 4704, A61K 3147
Patent
active
052409422
ABSTRACT:
The invention relates to compounds of formula I: ##STR1## in which R.sub.1 represents a naphthyl radical, a dihydronaphthyl radical, a tetrahydronaphthyl radical, a quinolyl radical or a 1,4-benzodioxanyl radical, A represents a single bond, a double bond, a methylene radical, a radical of formula z.sub.1 :
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patent: 4405789 (1983-09-01), Champseix
Wouters, et al., European Journal of Pharmacology, 149 (1988) 213-223 "Flesinoxan lowers blood pressure and heart rate in cats via 5-HT.sub.1A receptors".
Laubie, et al., European Journal of Pharmacology, 160 (1989) 385-394 "Ventrolated medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (.+-.)8-OH-DPAT in anaesthetized dogs".
Grohs, et al., Naunyn-Schmiedeberg's Arch Pharmacol (1990) 341, 472-475, "Cardiovascular effects of flesinoxan in anaesthetized and concious dogs".
Dabire, et al., European Journal of Pharmacology, 10 (1987) 259-266, "Comparison of effects of some 5-HT.sub.1 agonists on blood pressure and heart rate of normotensive anaesthetized rats".
Ramage, et al., European Journal of Pharmacology, 151 (1988) 373-379, "Evidence that the novel antihypertensive agent, flesinoxan, causes differential sympathoinhibition and also increases vagal tone by a central action".
Colpaert Francis
Laubie Michel
Lavielle Gilbert
Adir et Compagnie
Chang Celia
Hueschen Gordon W.
Ivy C. Warren
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