Treating or preventing ocular inflammation or systemic imflammat

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514912, A61K 3144

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active

052409368

ABSTRACT:
A novel compound for controlling (treatment and prevention) of ocular inflammation or systemic inflammatory disease is disclosed. The compound, OB-186, is effective at both the early and late phases of inflammation. The compound is useful for the treatment or prevention of inflammation in both the anterior and posterior portions of the eye and systemic inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, glyomerulonephritis, allergic inflammation and allergic encephalomyelitis.

REFERENCES:
Remington's Pharmaceutical Sciences. Fifteenth Edition 1975. pp. 1491-1492.
Ellis, Ocular Therapeutics and Pharmacology, C. B. Mosby Co., (1985) pp. 212-227.
Polansky et al., "Anti-Inflammatory Agents, Steroids as Anti-Inflammatory Agents" in Sears, ed., Handbook of Experimental Pharmacology, Springer-Verlag, (1985), 69: 459-538.
Miyano et al., [Ophthalmic Research, (1984), 16: 256-263.
Chiou et al., Journal of Ocular Pharmacology, (1985), 1: 383-390.
Bhattacherjee et al., "Effect of Lipoxygenase Products on Leukocyte Accumulation in the Rabbit Eye" in Samuelsson et al., Eds., Leukotrienes and Other Lipoxygenase Products, Raven Press, (1982), 325-330.
Chang et al., Journal of Ocular Pharmacology, (1989), 5: 353-360.

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